With every day that passed he became ever more despairing.
随着日子一天天过去，他越来越绝望。
One harsh word would send her into the depths of despair.
一句严厉的话就会使她陷入极度的绝望之中。
Don't despair! We'll think of a way out of this.
别灰心！我们会找到出路的。
The book describes a spiritual journey from despair to happiness.
这本书描述了从绝望到高兴的心理变化过程。
They'd almost despaired of ever having children.
他们对生孩子几乎不抱任何希望了。